Notes on Alzheimer’s, dementia and other neurodegenerative diseases: Testing & Treatment

The bulk of the information on this page is from Lee Euler of Awakening From Alzheimer’s, via email. If the item doesn’t list a different source, it is from Lee.

I’ve reorganized this list into categories; this posting is: 1. Testing & Treatment; See also: 2. Diet & Lifestyle; 3. Foods and Supplements; 4. Symptoms & Causes; 5. Related Diseases/Disorders.

Testing & Treatment

Testing for Dementia & Alzheimer’s 

The following table is from Mercola, 3/8/18 (5N); I saved graphic as Testing-Alzheimers_Mercola2018.png

Treatment: Herbal and other Natural Treatments

Black Seed Oil

This is an ancient remedy from Asia and the Mid-East, that has been used in traditional medicine for over 2,000 years due to its many therapeutic benefits that include protecting brain health, and reverse symptoms of metabolic syndrome and insulin resistance (48). See my Notes on Natural Health/Healing article: A – C, under “Black Seed Oil.” The following quotes support its use for brain health:

From Healthline (48):

Early test-tube and animal research suggests that thymoquinone in black seed oil may reduce neuroinflammation. Therefore, it may help protect against brain disorders like Alzheimer’s or Parkinson’s disease.” However, there has not been a lot of “research on its effectiveness in humans specifically regarding the brain.”… “One study in 40 healthy older adults found significant improvements in measures of memory, attention, and cognition after taking 500 mg of N. sativa capsules twice a day for 9 weeks.” [See the healthline article for its references.]

From Dietary Universe (49)

Black seed oil [from Nigella sativa seeds] contains thymol, thymoquinone (TQ) and thymohydroquinone (THQ). All these are natural chemicals that were put to test against 30 harmful pathogens and each of them came out scoring perfectly.”

“The study disclosed that no fungus or [mold] can withstand any of the three chemicals. Thymohydroquinone, one of the chemicals found in black seed oil turned out to be more effective fighting against mental conditions.”…Thymohydroquinone … is “one of the most potent ACHe inhibitors, it can prove to be effective in derailing the progression speed of any such mental condition.” [ACHe is abbreviation for the enzyme acetylcholine esterase. Inhibiting the ACHe enzyme is what gives thymohydroquinone its power over dementia and schizophrenia]. 

See also Nigella Sativa Center (50) for more info on black seed oil’s use for dementia.

Black Seed Oil Dosage,  to slow progress or reverse dementia:

I learned of its benefits concerning dementia from one of my friends. I will continue to research studies about this, and add my notes here. She suggests the following dosage twice daily (morning and evening); I would start at half-dose: 1 capsule, twice daily (1000 mg/day), and slowly work up to double that dose  (to 2000 mg/day) as follows:

    • 2 softgel/capsules, twice daily, for 1000 mg of black seed oil (500 mg per capsule); OR 
    • 2 tsp oil, twice daily, for 1000 mg of brand liquid black seed oil.

Most brands I checked out contain 500 mg black seed oil/capsule, and recommend 1 capsule, 2x daily, which is half the dose my friend suggested; for example:

  • The following contain 500 mg black seed oil/capsule, and recommend 1 capsule, 2x daily, (half the dose my friend suggested):
    • Health Harmony (Amazon ASIN B0714PK8VV) is the one my friend uses;
    • Life Extension (iHerb code LEX-17096);
    • Maju Organic brand. (Amazon ASIN B085DKNT97);
    • Pure Encapsulations (Amazon ASIN B0016L989G).
  • Another provides 650 mg black seed oil/capsule, and recommends up to 2 capsules, 2x daily:
    • Heritage Store (iHerb HRP-77406); has 4½ star (out of 5) rating from 27 reviews.

I will try Heritage Store brand, starting with 1 cap, 2x (1300 mg/day); then work up to 1 cap, 3x (1950 mg/day); if 1-3x doesn’t do the trick, I will try Health Harmony which has a 4½ star (out of 5) rating from over 11,000 positive ratings on Amazon.

PICK UP REVIEW HERE:

L-Carnitine

from a Lee Euler sales pitch (3I). This amino acid is important to recharge brain’s batteries. The article provides many references that include scientific studies in support of Acetyl L-Carnitine. “According to a study conducted at the University of Minnesota Medical School, one third of your brain’s energy goes toward cell maintenance. This is vital for keeping your brain tissue alive, healthy and functioning properly1 – so you can think and remember things quickly and easily.” The fuel includes glucose, but also fatty acids (fats), which are escorted across the blood-brain barrier by acetyl-L-carnitine (the simple amino acid L-carnitine is not enough, it needs the acetyl escort. Also it is a potent antioxidant that helps keep the brain from “rusting.

My thoughts: If you eat good quality meat daily, you may be getting enough L-carnitine (provided you chew it enough so that it gets digested). But inflammation in the brain may be an impediment.

Cerefolin-NAC, a prescription supplement

From Dr Glenn S Rothfeld’s Nutrition & Healing newsletter, 2018, pgs 6-7. Some insurance companies do not cover it, and it is not inexpensive. It is a prescription medication that is used to treat people with early memory loss and attention difficulties (43A). See also another supplement (43B)

Ingredients (43A):

  • 5.6 mg L-methylfolate (Metafolin) which is a biological form of folate
  • 2 mg Methylcobalamin (vitamin B12)
  • 600 mg N-Acetylcysteine (NAC), which is part of glutathione (an antioxidant).

My Mercola whole food multi (8 tabs daily dose) has much less of these, but I tend to have a food sensitivity to NAC in larger doses:

  • 665 mcg Metafolin
  • 100 mcg Methylcobalamin
  • 150 mg NAC

Cognitive training – it this the answer for Alzheimers?

(from Mercola (5o), 12/7/17) includes section on Mitochondrial Dysfunction being at the Heart of Alzheimer’s.

Essential oils: using them to support the brain and parasympathetic nervous system

A podcast with Jodi Sternoff Cohen and Wellness Mama (5);  I’ve saved copies of podcast and transcript to: HEALTH-NUTRITION > 1-DOCU-SERIES > AWAKENINGfmALZHEIMERS > PODCASTS & OTHER / essentialOils-Brain-ParasympatheticNervSyst_wellnessmama.mp3 and pdf

Diet:

ReCODE Protocol (includes diet and fasting recommendations to increase ketosis and autophagy)

See Mercola article: All Wrong About Alzheimers (5q) for more detail.

Big Pharma’s search for a “cure” was based on the assumption that amyloid beta is the cause of Alzheimer’s; but that search was a failure because the accumulation of amyloid beta is a symptom (the action of the body’s immune system), not the cause.

  • Dr Dale Bredesen’s ReCODE* protocol evaluates 150 factors, including biochemistry, genetics and historical imaging, known to contribute to Alzheimer’s disease
  • Bredesen has published a case report of 100 patients using the ReCODE protocol, in which all show sustained improvement in symptoms

‘* [Cat’s note: I don’t know if Dr. Bredesen’s ReCODE and M9 or MEND Protocols (next section) are the same, related, or totally separate. I suspect they are related.

Per Mercola’s article, Dr Bredesen has identified several types of Alzheimers:

  • Type 1 Alzheimer’s is “inflammatory” or “hot,” and patients present predominantly inflammatory symptoms.
  • Type 2 is atrophic or “cold,” with patients presenting an atrophic response.
  • Type 3, or toxic “vile” Alzheimer’s, where patients have toxic exposures.
  • Type 1.5 (a mixed type), or “sweet,” is a subtype that involves both inflammation and atrophy processes, due to insulin resistance and glucose-induced inflammation. An algorithm is used to determine a percentage for each subtype based on the variables evaluated, and an individualized treatment protocol is created.

Ketosis and autophagy are important dietary paths (5G):

“A hallmark of neurodegenerative diseases such as Alzheimer’s is that proteins are aggregated and typically misfolded. By inducing ketosis, improving insulin sensitivity and supporting the mitochondria, you can often regain the ability to refold or proteolyze misfolded proteins.”

“Autophagy [is] the process by which your body cleans out damaged organelles, which relates to Alzheimer’s because the refolding process is one of several factors that need to work in order for your brain to function. … Unfortunately, a vast majority of people do not have well-functioning autophagy, for the simple reason that they’re insulin-resistant.” Intermittent fasting improves autophagy, by “helping your body to cycle through autophagy and the rebuilding phase.”

Autophagy happens during the fasting period (typically during the night, from after dinner until breakfast in the morning). Dr. Bredensen recommends “12 to 14 hours of fasting if you are ApoE4-negative …; or 14 to 16 hours of fasting if you are 14 ApoE4-positive.”

Dr Bredensen recommends: “Measure your ketones. It’s simple to do. We want to get you into, ultimately, the 1.5 to 4.0 millimolar [range for] betahydroxybutyrate. That is the goal.” For testing your ketones, he suggests KetoCoachX, one of the least-expensive testing devices on the market. KetoMojo is also good, but more expensive. See reference (47) for more.

M9 (MEND or Metabolic Enhancement for Neuro Degeneration) Protocol, involving diet, lifestyle, supplements and minimal prescribed meds.

Dr Dale Bredesen did a study at UCLA regarding the theory that a toxin from the aluminum industry (AID3) is the cause of Alzheimer’s disease, and achieved the first true reversal of Alzheimer’s with the MEND protocol.  (See ABC News video/article (38) also UCLA Newsroom article (39)). See article on implementing the Bredesen Protocol (40) that has been “clinically shown to benefit Alzheimer’s patients.”

The protocol includes dietary and lifestyle changes; these changes may be different for each patient (see an article on a small study at UCLA and Buck Institute (41). These studies indicate the protocol works best for early-stage; those who were late-stage did not improve.

Bredesen’s approach is personalized to the patient, based on extensive testing to determine what is affecting the brain’s plasticity signaling network. In the case of the patient with the demanding job who was forgetting her way home, her therapy consisted of some, but not all, of the components of Bredesen’s program, including:

      • eliminating all simple carbohydrates, gluten and processed food from her diet, and eating more vegetables, fruits and non-farmed fish
      • meditating twice a day and beginning yoga to reduce stress
      • sleeping seven to eight hours per night, up from four to five
      • taking melatonin, methylcobalamin [methyl B12], vitamin D3, fish oil and coenzyme Q10 each day
      • optimizing oral hygiene using an electric flosser and electric toothbrush
      • reinstating hormone replacement therapy, which had previously been discontinued
      • fasting for a minimum of 12 hours between dinner and breakfast, and for a minimum of three hours between dinner and bedtime
      • exercising for a minimum of 30 minutes, four to six days per week”

See also related article by Dr Perlmutter (42) and an ABC News video (43) about brain-healthy fats (grass-fed meats, avocados and coconut oil).

Inclined Bed (6 degrees)

2/16/18:  You Tube video (46A) and Mercola article: (5P). This is not the same as raising the torso portion of your mattress; the entire mattress is tilted by 6 degrees. The video shows how to adjust your bed. The article provides the benefits of doing this.

Stimulate the glymphatic system.

7/2/18. The glymphatic system that clears debris from the brain, and also distributes non-waste compounds like fats, sugars and neurotransmitters through the brain’s extracellular and cerebrospinal fluids. So it’s important on two fronts. But glymphatic activity declines as we age, so we need to step it up. Three ways to do this:

  • Improve sleep, which improves the brain’s ability to clean itself. This means getting a good 8 hours of sleep each night (especially if doing intermittent fasting). 
  • Active exercise like walking/running, to create a rise in the heart rate (while exercising).
  • Low, daily alcohol consumption: works only with wine, and then only if 25 ml (about 3/4 ounce), which is 1/3 of a unit each day. Drinking a regular glass of wine causes glymphatic activity to plunge. Overconsumption of alcohol can lead to cancer and other issues. 

Dr Klinghardt on The Mechanics of Brain Detox (training session video, July 6, 2018 1:00 PM, Pacific or 2 PM Mtn) Webinar ID 967-133-310; register at link; view at Zoom link (original play), replay link, or on Facebook. Video is 86 min (1 hr, 26 min); it is mostly audio with powerpoint pages displayed along the way. Glymphatic system is major player in detoxing the brain; tonsils and sinuses also play a role, as do “binders.” When have tooth extraction, they secrete toxic inflammatory compounds 24/7 (how long do they continue to do this?

  • See also:

References

Lee Euler’s references:

These reference numbers are prefaced by “LE” in article above; for example, the first in the following list is LE1.

Other References:

  1. (2) American Academy of Neurology:eurekalert.org/pub_releases/2014-09/aaon-cyb091014.php; and Prevention: prevention.com/health/health-concerns/ab-blood-type-and-memory-problems
  2. (5) businesswire.com/news/home/20171101006063/en/Actor-Chuck-Norris-Wife-Gena-Norris-Announce
  3. Green Valley Natural Solutions:
    1. (15) greenvalleynaturalsolutions.com/TJR18/Triple_Joint_Relief-2.php
    2. (21) greenvalleynaturalsolutions.com/BVP/bvp-l-2-alt.php
    3. (22) greenvalleynaturalsolutions.com/ABP/abp-e-C.php
    4. greenvalleynaturalsolutions.com/ABP18/Advanced_Brain_Power-1.php
    5. greenvalleynaturalsolutions.com/TheraFlex/TheraFlexACN-A.php
    6. greenvalleynaturalsolutions.com/GEN/Genesis-B.php
    7. greenvalleynaturalsolutions.com/ALC/BE-ALC.php
    8. greenvalleynaturalsolutions.com/MMS/mms-trial-JPredo.php
    9. greenvalleynaturalsolutions.com/ALC/BE-ALC.php
  4. (13) Journal of Neuroscience: ncbi.nlm.nih.gov/pmc/articles/PMC4524974/
  5. Mercola:
    1. (17) articles.mercola.com/sites/articles/archive/2018/04/12/beets-may-help-prevent-alzheimers.aspx
    2. (18) articles.mercola.com/sites/articles/archive/2018/03/08/idiopathic-normal-pressure-hydrocephalus.aspx
    3. (19a) articles.mercola.com/sites/articles/archive/2018/04/15/pqq-berberine-mitochondrial-enhancers.aspx;
    4. (19b) articles.mercola.com/sites/articles/archive/2018/04/05/berberine-anxiety-depression.aspx;
    5. (19c) articles.mercola.com/sites/articles/archive/2018/05/05/extended-youth-extreme-longevity.aspx;
    6. (19d) articles.mercola.com/ketogenic-diet.aspx
    7. articles.mercola.com/sites/articles/archive/2018/05/24/how-excess-iron-raises-alzheimers-risk.aspx
    8. articles.mercola.com/sites/articles/archive/2018/05/03/lifestyle-factors-linked-to-alzheimers.aspx
    9. articles.mercola.com/sites/articles/archive/2019/01/24/nutrients-for-brain-health.aspx
    10. articles.mercola.com/sites/articles/archive/2018/06/18/green-tea-boosts-heart-brain-health.aspx
    11. articles.mercola.com/sites/articles/archive/2018/04/26/vitamin-d-deficiency-linked-to-dementia.aspx
    12. articles.mercola.com/sites/articles/archive/2014/05/28/vitamin-d-deficiency-signs-symptoms.aspx
    13. articles.mercola.com/sites/articles/archive/2018/07/04/60-ng-ml-vitamin-d-level-for-optimal-health.aspx
    14. articles.mercola.com/sites/articles/archive/2018/03/08/idiopathic-normal-pressure-hydrocephalus.aspx
    15. articles.mercola.com/sites/articles/archive/2017/12/07/cognitive-training-dementia.aspx
    16. articles.mercola.com/sites/articles/archive/2018/02/15/inclined-bed-therapy.aspx
    17. https://articles.mercola.com/sites/articles/archive/2020/02/27/all-wrong-about-alzheimers.aspx
  6. NCBI (Pub Med):
    1. (3) ncbi.nlm.nih.gov/pubmed/10782126/
    2. (4) ncbi.nlm.nih.gov/pubmed/12076218/
    3. (6) ncbi.nlm.nih.gov/pubmed/28653860
    4. (9) ncbi.nlm.nih.gov/pubmed/17167099
    5. (10) ncbi.nlm.nih.gov/pubmed/15212849
    6. ncbi.nlm.nih.gov/pubmed/25621434/
    7. ncbi.nlm.nih.gov/pmc/articles/PMC3926646/
    8. ncbi.nlm.nih.gov/pmc/articles/PMC4697050/
    9. ncbi.nlm.nih.gov/pmc/articles/PMC4314337/
    10. Hearing loss and incident dementia (ncbi.nlm.nih.gov/pubmed/21320988)
    11. ncbi.nlm.nih.gov/pmc/articles/PMC3153866/
    12. ncbi.nlm.nih.gov/pmc/articles/PMC5928071/
    13. ncbi.nlm.nih.gov/pubmed/32043639/
  7. (1) MIND Protocol article: newsmax.com/Health/Headline/MIND-protocol-lifestyle-plan/2015/04/06/id/636763/
  8. (11) Neurology Reviews (mdedge.com/neurologyreviews/article/114150/alzheimers-cognition/glymphatic-system-may-play-key-role-removing
  9. (16) Oregon State: lpi.oregonstate.edu/mic/dietary-factors/l-carnitine
  10. (8) Research Gate: researchgate.net/publication/283857212_Dose-dependent_hemorheological_effects_and_microcirculatory_modifications_following
    _intravenous_administration_of_Ginkgo_biloba_special_extract_EGb_761
  11. (7) Springer Link: link.springer.com/article/10.1007/s10534-016-9931-7
  12. (14) Stony Brook Medicine: americangeriatrics.org/sites/default/files/inline-files/Helene_Benveniste_MD_PhD.pdf
  13. (12) Stony Brook Newsroom: stonybrook.edu/newsroom/general/150804sleeping.php
  14. (20) superfoodly.com/health-benefits-of-high-pqq-foods-vs-supplement-sources/
  15. The following (15 and on) are new: TTAC (The Truth About Cancer) article links:
    1. Otto Warburg – Biographical (nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html)
    2. Otto Warburg – Award Ceremony Speech (nobelprize.org/nobel_prizes/medicine/laureates/1931/press.html)
    3. The Role of Oxygen, Antioxidants and Toxins in the Cancer Process (nobelprize.org/nobel_prizes/medicine/laureates/1931/press.html)
    4. A Rational Theory of Cancer (tbyil.com/Rational_Cancer_Theory.htm
  16. TTAC (The Truth About Cancer) general links:
    1. thetruthaboutcancer.com/solving-the-alzheimers-puzzle
  17. Neurology: Midlife cardiovascular fitness and dementia
    (n.neurology.org/content/early/2018/03/14/WNL.0000000000005290)
  18. Homocysteine imbalance connected to a higher risk of Alzheimer’s disease (naturalhealth365.com/homocysteine-science-news-2598.html)
  19. Dr Glen Rothfeld on HSV virus and Dementia:
    1. video transcript (This Deadly Sleeper Virus Triggers Alzheimers): pro.nutritionandhealing.com/p/NAH171211A/E640U963/Full or pro.nutritionandhealing.com/p/NAH181105A/E640UCCS/Full
    2. book: The Complete Guide to Reversing Alzheimer’s; see the purchase site (secure.nutritionandhealing.com/NAH171211A/E640U963/index.htm) or alternate purchase site (secure.nutritionandhealing.com/NAH181105A/E640UCCS/index.htm?pageNumber=2).
    3. See also: healthline.com/health-news/evidence-of-link-between-herpes-and-dementia#4); and (sciencedaily.com/releases/2018/10/181019100702.htm)————-Symptoms/Causes references ends at 19C; any I add after this need to be added to Symptoms/Causes if I want all pages to have same list.
  20. Green Med Info (Sayer Ji):
    1.  greenmedinfo.com/blog/7-proven-ways-keep-your-brain-young
    2. greenmedinfo.com/disease/aging-brain
    3. greenmedinfo.com/blog/natural-approach-preventing-and-overcoming-dementia
    4. foods, spices and the brain: greenmedinfo.com/blog/research-foodsspices-slow-perhaps-reverse-alzheimers
    5. greenmedinfo.com/blog/ginger-shows-promise-anti-alzheimers-agent
    6. greenmedinfo.com/substance/saffron
    7. greenmedinfo.com/blog/canola-oil-increases-memory-loss
    8. greenmedinfo.com/blog/brain-regeneration-why-its-real-how-do-it
    9. greenmedinfo.com/blog/daily-dose-turmeric-boosts-your-memory-and-improves-mood
    10. greenmedinfo.com/blog/how-turmeric-can-save-aging-brain-dementia-and-premature-death
    11.  
  21. Examine on bacopa-monnieriexamine.com/supplements/bacopa-monnieri
  22. Wikipedia:
    1. en.wikipedia.org/wiki/Glycogen
  23. Scicuious: scicurious.scientopia.org/2012/02/29/whats-fuel-for-the-body-is-fuel-for-the-brain-a-story-of-glycogen
  24. medicinenet.com/phenylketonuria/article.htm
  25. metabolicfactor.com/p/aff/quiz/42362 (or My link-to reference my info)
  26. Science Daily:
    1. sciencedaily.com/releases/2018/04/180416101403.htm
    2. sciencedaily.com/releases/2013/11/131115111524.htm
  27. frontiersin.org/articles/10.3389/fpsyg.2018.00487/full
  28. Mother Earth Living article:
    1. motherearthliving.com/gardening/plant-profile/healing-gotu-kola-zm0z18mazols includes among its references:
    2. (22b) cms.herbalgram.org/herbclip/104/review41815.html;
    3. (22c) umm.edu/health/medical/altmed/herb/gotu-kola;
    4. (22d) search.informit.com.au/documentSummary;dn=141015308096078;res=IELHEA ;
    5. (22e) cms.herbalgram.org/herbclip/362/review050281-362.html ;
    6. (22f)ncbi.nlm.nih.gov/pubmed/?term=centella+asiatica+startle
  29. Life Extension: lifeextension.com/Magazine/2008/4/New-Research-On-The-Health-Benefits-Of-Green-Tea/Page-01
  30. My food data: myfooddata.com/articles/high-choline-foods.php
  31. Web MD: webmd.com/balance/news/20030828/herb-sage-improves-memory
  32. Natural News:
    1. Improve Your Memory and Prevent Alzheimer’s with Sage (naturalnews.com/029693_memory_sage.html)
    2. Elderberry Trumps Tamiflu for Flu Remedy (naturalnews.com/026354_elderberry_Tamiflu_immune_system.html
  33. About “Genesis:” supplementpolice.com/genesis-green-valley-natural-solutions/
  34. nulogicnutritionals.com/brainlogic.html
  35. Dr Axe:
    1. draxe.com/what-is-choline/
    2. draxe.com/glycine/
    3. draxe.com/l-glutamine-benefits-side-effects-dosage/
    4. draxe.com/folate-deficiency/
    5. draxe.com/lutein/
    6. draxe.com/pqq-supplement/
  36. Gold Leaf Nutritionals:
    1. pro.goldleafnutritionals.com/p/GLN_cognigoldreboot_1018/MGLNUA76/Full
    2. goldleafnutritionals.com/products/cognigold/
  37. Alliance for Health: pro.allianceforadvancedhealth.com/p/AAH_alzaccidentfoureight_0618/EAAHV104/Full
  38. abc7news.com/health/non-drug-treatment-may-reverse-alzheimers/336963/
  39. newsroom.ucla.edu/releases/memory-loss-associated-with-alzheimers-reversed-for-first-time
  40. whitneyerd.com/2018/03/alzheimers-diet-bredesen-protocol.html
  41. newsroom.ucla.edu/releases/memory-loss-associated-with-alzheimers-reversed-for-first-time
  42. drperlmutter.com/anti-alzheimers-trio/
  43. abc7news.com/health/non-drug-treatment-may-reverse-alzheimers/336963/
  44. Brain Power:
    1. brainpower.org/reviews/cerefolin-nac.html
    2. brainpower.org/memory-loss/memory-loss-normal.html
  45. wellnessmama.com/podcast/essential-oil-blends/
  46. YouTube videos:
    1. youtube.com/watch?v=Hhg6L-2qT5A
  47. KetoCoach: ketocoachx.com
  48. Healthline: healthline.com/nutrition/black-seed-oil#benefits
  49. Dietary Universe: dietaryuniverse.com/can-black-cumin-seed-cure-dementia/
  50. nigellasativacenter.com/alzheimers-disease.html

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